Spence joined the Tottenham Hotspur Academy at the tender age of 10, quickly distinguishing himself as a disciplined and technically proficient defender. Over the years, he mastered the fundamentals of marking, interception, and positional awareness, all while developing a notable left‑foot crossing technique. His first professional appearance came in the 2019‑20 FA Cup against a lower‑division side, where his composure and stamina caught the eye of the senior coaching staff, leading to further opportunities in the league.
On the international stage, Spence represented England at under‑15, under‑16, and under‑21 levels before earning his first senior cap during the 2022 UEFA Nations League qualifiers. His performances consistently showcase a blend of defensive solidity and offensive support, making him a valuable asset in high‑pressure matches. Off the pitch, Spence is noted for his professional attitude and community involvement, frequently engaging in youth outreach programs that reflect the club’s commitment to social responsibility.